Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection. Academic Article uri icon

Overview

abstract

  • H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that conditioned media from infected glial cell cultures (supernatants) contain a factor unrelated to infectious virus and capable of inducing H-2 class I antigens on uninfected glial cells. The synthesis of this factor appears to be dependent on production of infectious virus since the H-2 inducing activity could not be detected 3 days following the addition of neutralizing antibodies to the cultures. This suggests that H-2 inducing activity contains an unstable component, the synthesis of which is dependent on continual virus production. Persistent MHV infection and H-2 class I antigen expression may play a role in MHV-induced demyelination.

publication date

  • April 1, 1989

Research

keywords

  • Hepatitis, Viral, Animal
  • Histocompatibility Antigens Class I
  • Neuroglia

Identity

PubMed Central ID

  • PMC7119878

Scopus Document Identifier

  • 0024498419

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(89)90040-4

PubMed ID

  • 2538490

Additional Document Info

volume

  • 22

issue

  • 2