Sentinel lymph node biopsy in the management of gynecologic cancer. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: To summarize current knowledge and recent advances in sentinel lymph node (SLN) concept in the three most frequent gynecological cancers. RECENT FINDINGS: In cervical cancer, SLN biopsy and ultrastaging has high sensitivity in lymph node staging in patients with bilaterally detected SLN. The presence of micrometastasis is associated with shortened survival. In endometrial cancer, SLN biopsy incorporating an institutional mapping algorithm and ultrastaging has been shown to significantly reduce false-negative rates and increase sensitivity and negative predictive value. SUMMARY: SLN biopsy and ultrastaging is useful in current management of patients with early-stage cervical cancer for multiple reasons, such as the reliable detection of key lymph nodes, identification of micrometastasis and intraoperative triage of patients. Although a complete or selective pelvic and paraaortic lymphadenectomy for adequate staging remains the standard treatment approach in patients with early-stage endometrial cancer, SLN biopsy has been shown to be safe and effective in detecting lymph node metastases. The application of the SLN procedure is safe in patients with early-stage unifocal squamous cell cancer of the vulva (<4 cm) and no suspicious enlarged lymph nodes at imaging.

publication date

  • February 1, 2015

Research

keywords

  • Endometrial Neoplasms
  • Fluoroscopy
  • Lymph Node Excision
  • Lymph Nodes
  • Uterine Cervical Neoplasms
  • Vulvar Neoplasms

Identity

Scopus Document Identifier

  • 84920809508

Digital Object Identifier (DOI)

  • 10.1097/GCO.0000000000000133

PubMed ID

  • 25502426

Additional Document Info

volume

  • 27

issue

  • 1