Severe persistent unremitting dermatitis, chronic diarrhea and hypoalbuminemia in a child; Hartnup disease in setting of celiac disease. uri icon

Overview

abstract

  • BACKGROUND: Celiac disease (CD) is a complex autoimmune disorder that can lead to an inflammatory small intestinal villous atrophy and malabsorption. Hartnup disease is an autosomal recessive disorder caused by increased urinary excretion of neutral amino acids. Co-occurrence of Hartnup disease and CD is extremely rare with only a single case reported. CASE PRESENTATION: We report a 3-year girl with chronic diarrhea, Hypoalbuminemia and exfoliative erythema. She was diagnosed with celiac disease, which did not improve on gluten free diet. Hartnup disease was suspected and was confirmed by neutral aminoaciduria. Niacin was started and followed by dramatic improvement. CONCLUSION: Presence of Celiac and Hartnup disease in single individual is very rare. Complete nutritional assessment of refractory celiac patient can reveal underlying nutritional deficiency.

publication date

  • December 20, 2014

Research

keywords

  • Celiac Disease
  • Dermatitis, Exfoliative
  • Diarrhea
  • Hartnup Disease
  • Hypoalbuminemia

Identity

PubMed Central ID

  • PMC4308912

Scopus Document Identifier

  • 84928674242

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2230.2008.02773.x

PubMed ID

  • 25526748

Additional Document Info

volume

  • 14