Dedifferentiated Liposarcoma of the Gastroesophageal Junction. uri icon

Overview

abstract

  • Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.

publication date

  • January 1, 2018

Research

keywords

  • Esophagogastric Junction
  • Liposarcoma
  • Stomach Neoplasms

Identity

PubMed Central ID

  • PMC7437155

Scopus Document Identifier

  • 84982217738

Digital Object Identifier (DOI)

  • 10.5146/tjpath.2014.01297

PubMed ID

  • 25690861

Additional Document Info

volume

  • 34

issue

  • 1