Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. METHODS: Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. RESULTS: At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. CONCLUSIONS: Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

authors

  • Pownall, Henry
  • Bray, George A
  • Wagenknecht, Lynne E
  • Walkup, Michael P
  • Heshka, Stanley
  • Hubbard, Van S
  • Hill, James
  • Kahn, Steven E
  • Nathan, David M
  • Schwartz, Anne V
  • Johnson, Karen C

publication date

  • March 1, 2015

Research

keywords

  • Body Composition
  • Diabetes Mellitus, Type 2
  • Life Style
  • Obesity
  • Overweight
  • Weight Reduction Programs

Identity

PubMed Central ID

  • PMC4707962

Scopus Document Identifier

  • 84925054062

Digital Object Identifier (DOI)

  • 10.1002/oby.21005

PubMed ID

  • 25707379

Additional Document Info

volume

  • 23

issue

  • 3