A randomized controlled trial of vitamin E and selenium on rate of decline in lung function. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The intake of nutrients with antioxidant properties is hypothesized to augment antioxidant defenses, decrease oxidant damage to tissues, and attenuate age-related rate of decline in lung function. The objective was to determine whether long-term intervention with selenium and/or vitamin E supplements attenuates the annual rate of decline in lung function, particularly in cigarette smokers. METHODS: The Respiratory Ancillary Study (RAS) tested the single and joint effects of selenium (200 μg/d L-selenomethionine) and vitamin E (400 IU/day all rac-α-tocopheryl acetate) in a randomized double-blind placebo-controlled trial. At the end of the intervention, 1,641 men had repeated pulmonary function tests separated by an average of 3 years. Linear mixed-effects regression models estimated the effect of intervention on annual rate of decline in lung function. RESULTS: Compared to placebo, intervention had no main effect on either forced expiratory volume in the first second (FEV1) or forced expiratory flow (FEF25-75). There was no evidence for a smoking by treatment interaction for FEV1, but selenium attenuated rate of decline in FEF25-75 in current smokers (P = 0.0219). For current smokers randomized to selenium, annual rate of decline in FEF25-75 was similar to the annual decline experienced by never smokers randomized to placebo, with consistent effects for selenium alone and combined with vitamin E. CONCLUSIONS: Among all men, there was no effect of selenium and/or vitamin E supplementation on rate of lung function decline. However, current smokers randomized to selenium had an attenuated rate of decline in FEF25-75, a marker of airflow. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT00241865 .

authors

  • Cassano, Patricia A.
  • Guertin, Kristin A
  • Kristal, Alan R
  • Ritchie, Kathryn E
  • Bertoia, Monica L
  • Arnold, Kathryn B
  • Crowley, John J
  • Hartline, JoAnn
  • Goodman, Phyllis J
  • Tangen, Catherine M
  • Minasian, Lori M
  • Lippman, Scott M
  • Klein, Eric

publication date

  • March 11, 2015

Research

keywords

  • Lung
  • Selenium
  • Smoking
  • Vitamin E

Identity

PubMed Central ID

  • PMC4404242

Scopus Document Identifier

  • 84928017544

Digital Object Identifier (DOI)

  • 10.1146/annurev-nutr-071811-150740

PubMed ID

  • 25889509

Additional Document Info

volume

  • 16

issue

  • 1