Vitamin B6 improves the immunogenicity of cisplatin-induced cell death. Academic Article uri icon

Overview

abstract

  • We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

publication date

  • December 13, 2014

Identity

PubMed Central ID

  • PMC4292417

Scopus Document Identifier

  • 84880747672

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2013.06.014

PubMed ID

  • 25941619

Additional Document Info

volume

  • 3

issue

  • 9