Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages. uri icon

Overview

abstract

  • Han et al. (this issue) describe a novel mechanism by which docosahexaenoic acid (DHA) may suppress atopic dermatitis symptoms in mice. They find that DHA induces FoxP3 T regulatory cells in vivo, M2 macrophages drive transforming growth factor-β and IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macrophages suppress atopic dermatitis in mice.

publication date

  • June 1, 2015

Research

keywords

  • Dermatitis, Atopic
  • Docosahexaenoic Acids
  • Interleukin-10
  • Macrophages
  • T-Lymphocytes, Regulatory
  • Transforming Growth Factor beta1

Identity

Scopus Document Identifier

  • 84938076451

Digital Object Identifier (DOI)

  • 10.1038/jid.2014.536

PubMed ID

  • 25964266

Additional Document Info

volume

  • 135

issue

  • 6