Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Academic Article uri icon

Overview

abstract

  • Imipenem with relebactam was active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing K. pneumoniae isolates affected the susceptibility of this combination. Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression. However, the addition of relebactam to imipenem did not provide added benefit against Acinetobacter baumannii. The combination of imipenem with relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.

publication date

  • May 26, 2015

Research

keywords

  • Acinetobacter baumannii
  • Azabicyclo Compounds
  • Enterobacteriaceae
  • Imipenem
  • Pseudomonas aeruginosa
  • beta-Lactamase Inhibitors

Identity

PubMed Central ID

  • PMC4505292

Scopus Document Identifier

  • 84939785073

Digital Object Identifier (DOI)

  • 10.1093/jac/dkt178

PubMed ID

  • 26014931

Additional Document Info

volume

  • 59

issue

  • 8