Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. Academic Article uri icon

Overview

abstract

  • To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.

publication date

  • May 27, 2015

Research

keywords

  • Antibodies, Viral
  • Epitopes
  • HIV-1
  • Primates
  • Simian Immunodeficiency Virus
  • Viral Envelope Proteins

Identity

PubMed Central ID

  • PMC4524233

Scopus Document Identifier

  • 84938125125

Digital Object Identifier (DOI)

  • 10.1016/j.jim.2014.11.006

PubMed ID

  • 26018159

Additional Document Info

volume

  • 89

issue

  • 16