Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission. Academic Article uri icon

Overview

abstract

  • Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, we aimed to define humoral immune correlates of risk of mother-to-child transmission (MTCT) of HIV-1, including responses associated with protection in the RV144 vaccine trial. Eighty-three untreated, HIV-1-transmitting mothers and 165 propensity score-matched nontransmitting mothers were selected from the Women and Infants Transmission Study (WITS) of US nonbreastfeeding, HIV-1-infected mothers. In a multivariable logistic regression model, the magnitude of the maternal IgG responses specific for the third variable loop (V3) of the HIV-1 envelope was predictive of a reduced risk of MTCT. Neutralizing Ab responses against easy-to-neutralize (tier 1) HIV-1 strains also predicted a reduced risk of peripartum transmission in secondary analyses. Moreover, recombinant maternal V3-specific IgG mAbs mediated neutralization of autologous HIV-1 isolates. Thus, common V3-specific Ab responses in maternal plasma predicted a reduced risk of MTCT and mediated autologous virus neutralization, suggesting that boosting these maternal Ab responses may further reduce HIV-1 MTCT.

authors

  • Permar, Sallie
  • Fong, Youyi
  • Vandergrift, Nathan
  • Fouda, Genevieve
  • Gilbert, Peter
  • Parks, Robert
  • Jaeger, Frederick H
  • Pollara, Justin
  • Martelli, Amanda
  • Liebl, Brooke E
  • Lloyd, Krissey
  • Yates, Nicole L
  • Overman, R Glenn
  • Shen, Xiaoying
  • Whitaker, Kaylan
  • Chen, Haiyan
  • Pritchett, Jamie
  • Solomon, Erika
  • Friberg, Emma
  • Marshall, Dawn J
  • Whitesides, John F
  • Gurley, Thaddeus C
  • Von Holle, Tarra
  • Martinez, David R
  • Cai, Fangping
  • Kumar, Amit
  • Xia, Shi-Mao
  • Lu, Xiaozhi
  • Louzao, Raul
  • Wilkes, Samantha
  • Datta, Saheli
  • Sarzotti-Kelsoe, Marcella
  • Liao, Hua-Xin
  • Ferrari, Guido
  • Alam, S Munir
  • Montefiori, David C
  • Denny, Thomas N
  • Moody, M Anthony
  • Tomaras, Georgia D
  • Gao, Feng
  • Haynes, Barton F

publication date

  • June 8, 2015

Research

keywords

  • HIV Antibodies
  • HIV Envelope Protein gp120
  • HIV Infections
  • HIV-1
  • Peptide Fragments
  • Pregnancy Complications, Infectious

Identity

PubMed Central ID

  • PMC4613557

Scopus Document Identifier

  • 84936797214

Digital Object Identifier (DOI)

  • 10.1016/j.jviromet.2007.02.015

PubMed ID

  • 26053661

Additional Document Info

volume

  • 125

issue

  • 7