Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation. Academic Article uri icon

Overview

abstract

  • Ipilimumab is a first-in-class immunological checkpoint blockade agent and monoclonal antibody against Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) that has demonstrated survival benefit and durable responses in patients with metastatic melanoma. To date, solid organ transplant recipients have been excluded from clinical trials with cancer immunotherapies on the basis of their concurrent treatment with immunosuppressive agents. We present the first case to our knowledge of a patient with advanced cutaneous melanoma receiving ipilimumab status post orthotopic liver transplantation with a partial response. Transaminitis was observed 4 months after administration of ipilimumab that resolved with close observation. No evidence of graft rejection has been observed to date. This case advocates for further investigation of the safety and efficacy of cancer immunotherapies in solid organ transplant recipients.

publication date

  • June 16, 2015

Identity

PubMed Central ID

  • PMC4469313

Scopus Document Identifier

  • 78650424492

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2010.10.059

PubMed ID

  • 26082835

Additional Document Info

volume

  • 3