BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma. uri icon

Overview

abstract

  • The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia.

publication date

  • April 28, 2015

Research

keywords

  • Oncogene Proteins, Fusion
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Proto-Oncogene Proteins c-bcr
  • Receptor, Platelet-Derived Growth Factor alpha

Identity

Scopus Document Identifier

  • 84939471329

Digital Object Identifier (DOI)

  • 10.1016/j.cancergen.2015.04.007

PubMed ID

  • 26095243

Additional Document Info

volume

  • 208

issue

  • 7-8