Blood-Brain Barrier Opening in Behaving Non-Human Primates via Focused Ultrasound with Systemically Administered Microbubbles. Academic Article uri icon

Overview

abstract

  • Over the past fifteen years, focused ultrasound coupled with intravenously administered microbubbles (FUS) has been proven an effective, non-invasive technique to open the blood-brain barrier (BBB) in vivo. Here we show that FUS can safely and effectively open the BBB at the basal ganglia and thalamus in alert non-human primates (NHP) while they perform a behavioral task. The BBB was successfully opened in 89% of cases at the targeted brain regions of alert NHP with an average volume of opening 28% larger than prior anesthetized FUS procedures. Safety (lack of edema or microhemorrhage) of FUS was also improved during alert compared to anesthetized procedures. No physiological effects (change in heart rate, motor evoked potentials) were observed during any of the procedures. Furthermore, the application of FUS did not disrupt reaching behavior, but in fact improved performance by decreasing reaction times by 23 ms, and significantly decreasing touch error by 0.76 mm on average.

publication date

  • October 26, 2015

Research

keywords

  • Blood-Brain Barrier
  • Primates

Identity

PubMed Central ID

  • PMC4620488

Scopus Document Identifier

  • 84945248746

Digital Object Identifier (DOI)

  • 10.1093/acprof:oso/9780195070019.001.0001

PubMed ID

  • 26496829

Additional Document Info

volume

  • 5