Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy. Review uri icon

Overview

abstract

  • Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

publication date

  • January 1, 2015

Research

keywords

  • Atherosclerosis
  • Endothelium, Vascular
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Signal Transduction

Identity

PubMed Central ID

  • PMC4666423

Scopus Document Identifier

  • 85015987494

Digital Object Identifier (DOI)

  • 10.14797/mdcj-11-3-166

PubMed ID

  • 26634024

Additional Document Info

volume

  • 11

issue

  • 3