Strategies to target non-T-cell HIV reservoirs. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.

publication date

  • July 1, 2016

Research

keywords

  • Drug Therapy
  • HIV
  • HIV Infections
  • Immunotherapy
  • Virus Latency
  • Virus Replication

Identity

PubMed Central ID

  • PMC4947377

Scopus Document Identifier

  • 84961956354

Digital Object Identifier (DOI)

  • 10.1097/COH.0000000000000283

PubMed ID

  • 27023285

Additional Document Info

volume

  • 11

issue

  • 4