Lactulose Hydrogen Breath Test Result Is Associated with Age and Gender. Academic Article uri icon

Overview

abstract

  • Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to lactulose hydrogen breath test (LHBT) result. Methods. A cross-sectional study in a university-based gastroenterology practice was performed. Data was abstracted from the medical records of subjects undergoing LHBT from 6/1/2009 to 6/1/2013. Logistic regression analysis was performed to determine the association between predictor variables: age, sex, body mass index (BMI), and positive LHBT, the outcome of interest. Results. LHBT was performed in 791 subjects. Fifty-four percent had a positive LHBT. There was no statistically significant difference between the LHBT results according to age or BMI. In females, the likelihood of a positive LHBT increased with age (OR 1.02; 95% CI: 1.01-1.03). In males, the likelihood of a positive LHBT result decreased with age (OR 0.98; 95% CI: 0.97-1.00). Conclusion. There was an association between age, with respect to sex, and a positive LHBT. With increased age in females, the odds of a positive LHBT increased, while, in men, the odds of a positive LHBT decreased with age.

publication date

  • March 17, 2016

Research

keywords

  • Aging
  • Bacterial Infections
  • Breath Tests
  • Intestine, Small

Identity

PubMed Central ID

  • PMC4814632

Scopus Document Identifier

  • 84962911450

Digital Object Identifier (DOI)

  • 10.1210/en.2007-1597

PubMed ID

  • 27073800

Additional Document Info

volume

  • 2016