Poly(ADP-Ribose) Polymerases in Aging - Friend or Foe? Review uri icon

Overview

abstract

  • Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

publication date

  • January 1, 2016

Research

keywords

  • Aging
  • Poly(ADP-ribose) Polymerases

Identity

Scopus Document Identifier

  • 84989233687

Digital Object Identifier (DOI)

  • 10.2174/1389203717666160419144959

PubMed ID

  • 27090903

Additional Document Info

volume

  • 17

issue

  • 7