RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function. Review uri icon

Overview

abstract

  • Recent human and mouse genetic studies have highlighted important contributions of several small GTPases, in particular Rab8a, (1) Cdc42, (2-4) and Rab11a, (5-8) to the proper morphogenesis and function of the mature intestinal epithelia. Additional insights about the involvement of these factors in maintaining intestinal stem cell homeostasis have also been obtained. (9,10) These studies suggest a conserved vesicular and membrane trafficking program utilized by the gastrointestinal tissue to support the rapid epithelial cell turnover and the highly sophisticated physiology of mature epithelial cells.

publication date

  • May 4, 2016

Research

keywords

  • Enterocytes
  • Homeostasis
  • rab GTP-Binding Proteins
  • rho GTP-Binding Proteins

Identity

PubMed Central ID

  • PMC4905260

Scopus Document Identifier

  • 84965031784

Digital Object Identifier (DOI)

  • 10.1136/gutjnl-2013-304570

PubMed ID

  • 27142493

Additional Document Info

volume

  • 7

issue

  • 2