Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia. uri icon

Overview

abstract

  • Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution.

publication date

  • May 5, 2016

Research

keywords

  • Autoradiography
  • Cryosurgery
  • Neoplasms, Connective Tissue
  • Octreotide
  • Positron Emission Tomography Computed Tomography

Identity

PubMed Central ID

  • PMC5483397

Scopus Document Identifier

  • 84966351266

Digital Object Identifier (DOI)

  • 10.1007/s00270-016-1350-1

PubMed ID

  • 27150801

Additional Document Info

volume

  • 39

issue

  • 9