Acute systemic organ injury in term infants after asphyxia. Academic Article uri icon

Overview

abstract

  • The systemic manifestations of "asphyxia" were evaluated prospectively in 35 consecutively intubated term newborn infants. The following systemic organ injuries were identified most often: (1) renal, ie, oliguria less than 1 mL/kg per hour for at lest 24 hours (40%), an elevated urinary beta-2-microglobulin concentration (57%), azotemia (11%), and an elevated serum creatinine level (17%); (2) central nervous system, ie, hypoxic-ischemic encephalopathy (including seizures) (31%) or an abnormal cranial ultrasound scan, ie, diffuse parenchymal echogenicity, slitlike ventricles, and poor visualization of the sulci, and/or intracranial hemorrhage (26%); (3) cardiovascular, ie, an abnormal echocardiogram (25%) or abnormal electrocardiogram (11%); (4) pulmonary complications, including persistent pulmonary hypertension (23%); and (5) gastrointestinal complications, which were rare. Traditional markers of fetal distress were not related to the frequency and/or distribution of systemic organ injury. An important implication of this study relates to the recognition of the extent and distribution of organ injury in the "asphyxiated" infant.

publication date

  • May 1, 1989

Research

keywords

  • Asphyxia Neonatorum
  • Cardiovascular Diseases
  • Central Nervous System Diseases
  • Gastrointestinal Diseases
  • Kidney Diseases
  • Lung Diseases

Identity

Scopus Document Identifier

  • 0024561757

Digital Object Identifier (DOI)

  • 10.1001/archpedi.1989.02150170119037

PubMed ID

  • 2718998

Additional Document Info

volume

  • 143

issue

  • 5