Taspase 1: A protease with many biological surprises. Academic Article uri icon

Overview

abstract

  • Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a "non-oncogene addiction" protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

publication date

  • January 23, 2015

Identity

PubMed Central ID

  • PMC4905357

Scopus Document Identifier

  • 85046638385

Digital Object Identifier (DOI)

  • 10.1038/cr.2014.129

PubMed ID

  • 27308523

Additional Document Info

volume

  • 2

issue

  • 4