Short- and long-term outcomes of adult allogeneic hematopoietic stem cell transplant patients admitted to the intensive care unit in the peritransplant period. Academic Article uri icon

Overview

abstract

  • Survival of allogeneic hematopoietic stem cell transplant (aHSCT) recipients in the intensive care unit (ICU) has been poor. We retrospectively analyzed the short- and long-term outcomes of aHSCT patients admitted to the ICU over a 12-year period. Of 1235 adult patients who had aHSCT between 2002 and 2013, 161 (13%) were admitted to the ICU. The impact of clinical parameters was assessed and outcomes were compared for the periods 2002-2007 and 2008-2013. The ICU, in-hospital, 1- and 5-year survival rates were 64.6%, 46%, 33% and 20%, respectively. Mechanical ventilation and vasopressor use predicted for worse hospital- and overall survival (OS). After 2008, the requirement for mechanical ventilation and vasopressors, and the diagnosis of sepsis were reduced. While hospital mortality decreased from 69% to 44%, long-term survival (LTS) remained unchanged. Late deaths, due to causes not associated with the ICU such as relapse and graft-versus-host disease, increased. As thresholds for transplant are lowered, improvements in ICU outcomes for aHSCT recipients may be limited.

publication date

  • June 27, 2016

Research

keywords

  • Critical Care
  • Hematopoietic Stem Cell Transplantation
  • Intensive Care Units
  • Patient Admission

Identity

PubMed Central ID

  • PMC5581948

Scopus Document Identifier

  • 84976307722

Digital Object Identifier (DOI)

  • 10.1080/10428194.2016.1195499

PubMed ID

  • 27347608

Additional Document Info

volume

  • 58

issue

  • 2