Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Academic Article uri icon

Overview

abstract

  • Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticancer immunity) from autophagy-competent, but not autophagy-deficient, mutant KRAS-induced lung cancers in mice, thereby improving anticancer immunosurveillance and reducing tumor mass. Short-term fasting or treatment with several chemically unrelated autophagy-inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by chemotherapy in vivo. This effect was only observed for autophagy-competent tumors, depended on the presence of T lymphocytes, and was accompanied by the depletion of regulatory T cells from the tumor bed.

authors

publication date

  • July 11, 2016

Research

keywords

  • Citrates
  • Neoplasms, Experimental
  • Spermidine
  • T-Lymphocytes, Regulatory

Identity

PubMed Central ID

  • PMC5715805

Scopus Document Identifier

  • 84979780741

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2016.05.016

PubMed ID

  • 27411589

Additional Document Info

volume

  • 30

issue

  • 1