Flow cytometric analysis of malignant pleural mesotheliomas. Academic Article uri icon

Overview

abstract

  • Forty-six cases of malignant pleural mesothelioma were analyzed for histologic subtype, DNA content, and cell cycle characteristics. Sixty-five percent of cases were diploid in DNA content, with intermediate to low proliferative rates. Thirty-one nonmesothelial malignant neoplasms of the lung, of histologic types most easily confused with malignant mesothelioma, were also examined. In contrast to the mesotheliomas, 85% of these nonmesothelial malignant neoplasms of the lung were aneuploid; the aneuploid neoplasms exhibited higher mean proliferative rates (S = 10.6%) than diploid nonmesothelial neoplasms of the lung (S less than 6%). Unlike most malignant neoplasms, mesotheliomas most often display diploid DNA contents and low proliferative rates despite their clinically aggressive behavior.

publication date

  • August 1, 1989

Research

keywords

  • Flow Cytometry
  • Mesothelioma
  • Pleural Neoplasms

Identity

Scopus Document Identifier

  • 0024323987

Digital Object Identifier (DOI)

  • 10.1016/0046-8177(89)90072-5

PubMed ID

  • 2744749

Additional Document Info

volume

  • 20

issue

  • 8