Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network. Academic Article uri icon

Overview

abstract

  • Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis (p = 0.04) and understand non-verbal communication (p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1.

publication date

  • October 1, 2016

Research

keywords

  • Autism Spectrum Disorder
  • Community Networks
  • Diagnostic and Statistical Manual of Mental Disorders
  • Neurofibromatosis 1

Identity

PubMed Central ID

  • PMC5494711

Scopus Document Identifier

  • 84979986254

Digital Object Identifier (DOI)

  • 10.1007/s10803-016-2877-3

PubMed ID

  • 27465244

Additional Document Info

volume

  • 46

issue

  • 10