Developing a Clinically Representative Model of Periprosthetic Joint Infection. Review uri icon

Overview

abstract

  • ➤The poor treatment outcomes for periprosthetic joint infection (PJI) reflect the limited understanding that currently exists regarding the pathogenesis of this devastating clinical problem.➤Current animal models of PJI are limited in their translational nature primarily because of their inability to recreate the periprosthetic environment.➤A greater mechanistic understanding of the musculoskeletal and immune systems of small animals, such as mice and rats, provides a more robust platform for modeling and examining the pathogenesis of PJI.➤A clinically representative PJI model must involve an implant that recreates the periprosthetic space and be amenable to methodologies that identify implant biofilm as well as quantify the peri-implant bacterial load.

publication date

  • October 5, 2016

Research

keywords

  • Disease Models, Animal
  • Prosthesis-Related Infections

Identity

Scopus Document Identifier

  • 85010064553

Digital Object Identifier (DOI)

  • 10.2106/JBJS.15.01432

PubMed ID

  • 27707853

Additional Document Info

volume

  • 98

issue

  • 19