Successful Treatment of a Patient with Glioblastoma and a Germline POLE Mutation: Where Next?
Overview
abstract
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Hypermutation and elevated neoantigen count in glioblastoma occurred in a patient harboring a germline POLE mutation and are associated with a clinical and antitumor immune response to PD-1 blockade. Cancer Discov; 6(11); 1210-11. ©2016 AACR.See related article by Johanns et al., p. 1230.
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Research
keywords
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DNA Polymerase II
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Glioblastoma
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Programmed Cell Death 1 Receptor
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PubMed Central ID
Scopus Document Identifier
Digital Object Identifier (DOI)
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10.1158/2159-8290.CD-16-1056
PubMed ID
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