Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo. Academic Article uri icon

Overview

abstract

  • Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

publication date

  • December 20, 2016

Research

keywords

  • Amines
  • Nanostructures
  • Polymers
  • RNA, Small Interfering

Identity

PubMed Central ID

  • PMC5216453

Scopus Document Identifier

  • 85006858162

Digital Object Identifier (DOI)

  • 10.1021/acs.nanolett.5b02428

PubMed ID

  • 27921096

Additional Document Info

volume

  • 5

issue

  • 1