Autoimmune-Related Retinopathy and Optic Neuropathy Accompanied by Anti-GAD Antibodies. uri icon

Overview

abstract

  • Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

publication date

  • July 15, 2015

Identity

PubMed Central ID

  • PMC5123164

Scopus Document Identifier

  • 84946057546

Digital Object Identifier (DOI)

  • 10.3109/01658107.2015.1050744

PubMed ID

  • 27928356

Additional Document Info

volume

  • 39

issue

  • 4