Development of a Searchable Database of Cryoablation Simulations for Use in Treatment Planning. Academic Article uri icon

Overview

abstract

  • PURPOSE: To create and validate a planning tool for multiple-probe cryoablation, using simulations of ice ball size and shape for various ablation probe configurations, ablation times, and types of tissue ablated. MATERIALS AND METHODS: Ice ball size and shape was simulated using the Pennes bioheat equation. Five thousand six hundred and seventy different cryoablation procedures were simulated, using 1-6 cryoablation probes and 1-2 cm spacing between probes. The resulting ice ball was measured along three perpendicular axes and recorded in a database. Simulated ice ball sizes were compared to gel experiments (26 measurements) and clinical cryoablation cases (42 measurements). The clinical cryoablation measurements were obtained from a HIPAA-compliant retrospective review of kidney and liver cryoablation procedures between January 2015 and February 2016. Finally, we created a web-based cryoablation planning tool, which uses the cryoablation simulation database to look up the probe spacing and ablation time that produces the desired ice ball shape and dimensions. RESULTS: Average absolute error between the simulated and experimentally measured ice balls was 1 mm in gel experiments and 4 mm in clinical cryoablation cases. The simulations accurately predicted the degree of synergy in multiple-probe ablations. The cryoablation simulation database covers a wide range of ice ball sizes and shapes up to 9.8 cm. CONCLUSION: Cryoablation simulations accurately predict the ice ball size in multiple-probe ablations. The cryoablation database can be used to plan ablation procedures: given the desired ice ball size and shape, it will find the number and type of probes, probe configuration and spacing, and ablation time required.

publication date

  • January 3, 2017

Research

keywords

  • Cryosurgery
  • Databases, Factual
  • Kidney
  • Liver

Identity

PubMed Central ID

  • PMC5374014

Scopus Document Identifier

  • 85008186481

Digital Object Identifier (DOI)

  • 10.1007/s00270-016-1562-4

PubMed ID

  • 28050658

Additional Document Info

volume

  • 40

issue

  • 5