Estradiol and progesterone replacement regimens for the induction of endometrial receptivity. Academic Article uri icon

Overview

abstract

  • Initiation of pregnancy in premature ovarian failure patients by use of donated oocytes fertilized in vitro requires establishment of a normal endometrial environment. We compared administration of estradiol (E2) and progesterone (P) by polysiloxane vaginal rings versus oral micronized E2 and P vaginal suppositories in 10 such patients. Serum E2 levels were similar between groups and similar to normally-cycling controls. With vaginal administration of E2, a burst effect was noted, with marked elevation 1 hour after insertion. The pattern with oral administration was more consistent, although marked conversion to estrone occurred. The P cylinder and suppositories delivered similar levels, with diminution of P in some patients with the cylinder. Despite apparent limitations, endometrial histology was normal after each cycle; both groups achieved pregnancies. Administration of E2 and P by polysiloxane vaginal rings achieved hormonal levels similar to oral micronized E2 and P vaginal suppositories. Endometrial biopsies after the stimulated cycle were appropriately mature.

publication date

  • November 1, 1989

Research

keywords

  • Endometrium
  • Estradiol
  • Progesterone

Identity

Scopus Document Identifier

  • 0024456877

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)61027-0

PubMed ID

  • 2806616

Additional Document Info

volume

  • 52

issue

  • 5