Long Non-Coding RNA as Potential Biomarker for Prostate Cancer: Is It Making a Difference? Review uri icon

Overview

abstract

  • Whole genome transcriptomic analyses have identified numerous long non-coding RNA (lncRNA) transcripts that are increasingly implicated in cancer biology. LncRNAs are found to promote essential cancer cell functions such as proliferation, invasion, and metastasis, with the potential to serve as novel biomarkers of various cancers and to further reveal uncharacterized aspects of tumor biology. However, the biological and molecular mechanisms as well as the clinical applications of lncRNAs in diverse diseases are not completely understood, and remain to be fully explored. LncRNAs may be critical players and regulators in prostate cancer carcinogenesis and progression, and could serve as potential biomarkers for prostate cancer. This review focuses on lncRNA biomarkers that are already available for clinical use and provides an overview of lncRNA biomarkers that are under investigation for clinical development in prostate cancer.

publication date

  • March 7, 2017

Research

keywords

  • Prostatic Neoplasms
  • RNA, Long Noncoding

Identity

PubMed Central ID

  • PMC5369106

Scopus Document Identifier

  • 85014782748

Digital Object Identifier (DOI)

  • 10.1007/s12253-013-9618-0

PubMed ID

  • 28272371

Additional Document Info

volume

  • 14

issue

  • 3