Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: We review recent evidence for circadian rhythm dysregulation in bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in the biological clock and disruptions in the external entrainment of circadian rhythms in BSDs. We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD. RECENT FINDINGS: Relative circadian phase delay (e.g., later melatonin peak, evening chronotype) is associated with BSD, particularly in the depressive phase. More consistent evidence supports irregularity of social rhythms, sleep/wake and activity patterns, and disruptions of social rhythms by life events, as stable trait markers of BSD and potential vulnerabilities for BSD onset. Growing research supports an integrative reward/circadian model. Both endogenous abnormalities in the biological clock pacemaking function and disruptions in the external entrainment of circadian rhythms by physical and social cues are involved in BSDs. Circadian dysregulation may provide vulnerability to BSD onset.

publication date

  • April 1, 2017

Research

keywords

  • Bipolar Disorder
  • Chronobiology Disorders

Identity

PubMed Central ID

  • PMC6661150

Scopus Document Identifier

  • 85015958439

Digital Object Identifier (DOI)

  • 10.1155/2012/978962

PubMed ID

  • 28321642

Additional Document Info

volume

  • 19

issue

  • 4