Asymmetric Notch Amplification to Secure Stem Cell Identity. uri icon

Overview

abstract

  • Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

publication date

  • March 27, 2017

Research

keywords

  • Receptors, Notch
  • Stem Cells

Identity

PubMed Central ID

  • PMC5490801

Scopus Document Identifier

  • 85016453328

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2017.03.010

PubMed ID

  • 28350981

Additional Document Info

volume

  • 40

issue

  • 6