A Comparison of Yttrium-90 Microsphere Radioembolization to Hepatic Arterial Infusional Chemotherapy for Patients with Chemo-refractory Hepatic Colorectal Metastases. Academic Article uri icon

Overview

abstract

  • Patients with unresectable hepatic colorectal metastases who become chemo-refractory have limited treatment options. Systemic chemotherapies such as TAS102 and regorafenib have been used in the refractory setting, but with only modest improvement in overall survival compared to best supportive care. In patients with liver-only or liver-dominant disease, direct chemotherapy to the liver such as hepatic artery infusional (HAI) chemotherapy and radioembolization (yttrium-90 (Y90)) should be considered. Due to the difficulty of HAI therapy post Y90 for technical reasons, we recommend HAI therapy prior to Y90.

publication date

  • July 1, 2017

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Colorectal Neoplasms
  • Embolization, Therapeutic
  • Liver Neoplasms
  • Microspheres
  • Radiopharmaceuticals
  • Yttrium Radioisotopes

Identity

Scopus Document Identifier

  • 85020503641

Digital Object Identifier (DOI)

  • 10.1007/s11864-017-0481-1

PubMed ID

  • 28608276

Additional Document Info

volume

  • 18

issue

  • 7