BAK regulates catalase release from peroxisomes. Academic Article uri icon

Overview

abstract

  • Loss of voltage-dependent anion channel 2 (VDAC2) leads to impaired peroxisome biogenesis in mammalian cells. Knockdown of BAK restores peroxisomal biogenesis in VDAC2-deficient cells, where BAK localization shifts from mitochondria to peroxisomes. Moreover, overexpression of BAK activators in wild-type cells permeabilizes peroxisomes in a BAK-dependent manner. Together, BAK most likely regulates peroxisomal membrane permeability.

publication date

  • March 17, 2017

Identity

PubMed Central ID

  • PMC5462519

Digital Object Identifier (DOI)

  • 10.1038/ncb3236

PubMed ID

  • 28616584

Additional Document Info

volume

  • 4

issue

  • 3