Phylogenetic analysis reveals two genotypes of the emerging fungus Mucor indicus, an opportunistic human pathogen in immunocompromised patients. Review uri icon

Overview

abstract

  • Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery. M. indicus can infect a wide variety of patients with no real preference for the site of infection. We concluded that M. indicus has emerged as a significant cause of invasive mycosis in severely immunocompromised patients worldwide. Early diagnosis and initiation of appropriate therapy could enhance survival in these immunocompromised patient populations.

publication date

  • July 12, 2017

Research

keywords

  • Immunocompromised Host
  • Mucor
  • Mucormycosis
  • Phylogeny

Identity

PubMed Central ID

  • PMC5567167

Scopus Document Identifier

  • 85023187453

Digital Object Identifier (DOI)

  • 10.1038/emi.2017.51

PubMed ID

  • 28698667

Additional Document Info

volume

  • 6

issue

  • 7