Persistence of Candida dubliniensis and lung function in patients with cystic fibrosis. Academic Article uri icon

Overview

abstract

  • OBJECTIVES: Candida dubliniensis is an emerging yeast and demonstrated a high adherence property to cystic fibrosis respiratory tract. Therefore, it is important to determine the persistence of C. dubliniensis and to assess the possible relationship to the body mass index (BMI) and forced expiratory volume in 1st second (FEV1). RESULTS: Candida isolates were identified by MALDI-TOF MS to species level from 40/52 (76.9%) cystic fibrosis patients. C. dubliniensis was the most common organism isolated from 50/77 (65%) lower respiratory specimens of 29 patients. Patients with persistent C. dubliniensis isolates have higher mean BMI in comparison to intermittent C. dubliniensis group. However, this difference did not reach statistical significance (P = 0.539). In contrast, patients with persistent C. dubliniensis isolates have significantly lower FEV1% mean in comparison to intermittent C. dubliniensis group particularly at initial two visits (P < 0.05); however, at subsequent visit the difference observed was not statistically significant (P = 0.456). The persistence of C. dubliniensis is more frequent in adults having more advanced disease, co-infections with chronic P. aeruginosa, cystic fibrosis related diabetes, long-term nebulized tobramycin and oral Zithromax therapy than patients with intermittent C. dubliniensis. Patients with persistent C. dubliniensis have lower FEV1 percentage and higher BMI than the intermittent C. dubliniensis.

publication date

  • July 26, 2017

Research

keywords

  • Body Mass Index
  • Candida
  • Candidiasis
  • Cystic Fibrosis
  • Forced Expiratory Volume

Identity

PubMed Central ID

  • PMC5530559

Scopus Document Identifier

  • 85026325891

Digital Object Identifier (DOI)

  • 10.3945/ajcn.112.051409

PubMed ID

  • 28747217

Additional Document Info

volume

  • 10

issue

  • 1