The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.

Overview

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR^mt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR^mt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR^mt in other diseases is also emerging and is therefore also briefly discussed.