Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression. Academic Article uri icon

Overview

abstract

  • Individuals who exhibit long-term HIV suppression and CD4 T-cell preservation without antiretroviral therapy are of great interest for HIV research. There is currently no robust method for rapid identification of these "HIV controller" subjects; however, HLA-B*57 (human leukocyte antigen (major histocompatibility complex), class I, B*57) genotype exhibits modest sensitivity for this phenotype. Complement C3b and C4b can influence HIV infection and replication, but studies have not examined their possible link to HIV controller status. We analyzed HLA-B*57 genotype and complement levels in HIV-positive patients receiving suppressive antiretroviral therapy, untreated HIV controllers, and HIV-negative subjects to identify factors associated with HIV controller status. Our results revealed that the plasma levels of three C4b-derived peptides and complement factor I outperformed all other assayed biomarkers for HIV controller identification, although we could not analyze the predictive value of biomarker combinations with the current sample size. We believe this rapid screening approach may prove useful for improved identification of HIV controllers.

publication date

  • September 15, 2017

Research

keywords

  • Complement C4b
  • Complement Factor I
  • HIV Infections

Identity

PubMed Central ID

  • PMC5727467

Scopus Document Identifier

  • 85038217749

Digital Object Identifier (DOI)

  • 10.1038/srep09327

PubMed ID

  • 28862830

Additional Document Info

volume

  • 3

issue

  • 12