PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation. Review uri icon

Overview

abstract

  • Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment.

publication date

  • September 11, 2017

Research

keywords

  • Chromosome Segregation
  • PTEN Phosphohydrolase

Identity

PubMed Central ID

  • PMC5659364

Scopus Document Identifier

  • 85029063787

Digital Object Identifier (DOI)

  • 10.1038/onc.2017.113

PubMed ID

  • 28891157

Additional Document Info

volume

  • 39

issue

  • 10