Ets transcription factor GABP controls T cell homeostasis and immunity. Academic Article uri icon

Overview

abstract

  • Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.

publication date

  • October 20, 2017

Research

keywords

  • GA-Binding Protein Transcription Factor
  • T-Lymphocytes

Identity

PubMed Central ID

  • PMC5648787

Scopus Document Identifier

  • 85031902719

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2010.05.004

PubMed ID

  • 29051483

Additional Document Info

volume

  • 8

issue

  • 1