A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes. Academic Article uri icon

Overview

abstract

  • Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain Aβ and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD.

publication date

  • October 26, 2017

Research

keywords

  • Alzheimer Disease
  • Brain
  • Guanidine
  • Inositol
  • Phenotype

Identity

PubMed Central ID

  • PMC5658413

Scopus Document Identifier

  • 85032486026

Digital Object Identifier (DOI)

  • 10.1007/BF00234656

PubMed ID

  • 29074878

Additional Document Info

volume

  • 7

issue

  • 1