Understanding the impact of hypoglycemia on the cardiovascular system. Academic Article uri icon

Overview

abstract

  • INTRODUCTION: Hypoglycemia occurs commonly in insulin requiring individuals with either Type 1 or Type 2 Diabetes. AREAS COVERED: This article will review recent information on the pro-inflammatory and pro-atherothrombotic effects of hypoglycemia. Additionally, effects of hypoglycemia on arrhythmogenic potential and arterial endothelial dysfunction will be discussed. Effects of hypoglycemia on cardiovascular morbidity and mortality from large clinical studies in Type 1 and Type 2 DM will also be reviewed. EXPERT COMMENTARY: The relative and absolute risk of severe hypoglycemia leading to death and serious adverse events in both cardiovascular and other organ systems has been highlighted following the publication of recent large clinical trials focused on glucose control and outcomes. It would be helpful if future studies could develop broader end points to include minor and moderate hypoglycemia as well as more robust methods for capturing hypoglycemia contemporaneously with adverse events. In addition, perhaps consideration of including hypoglycemia as a primary outcome, may help identify the possible cause and effect of hypoglycemia on cardiovascular morbidity and mortality.

publication date

  • January 5, 2017

Identity

PubMed Central ID

  • PMC5669378

Scopus Document Identifier

  • 85008471605

Digital Object Identifier (DOI)

  • 10.1016/j.diabet.2015.03.001

PubMed ID

  • 29109754

Additional Document Info

volume

  • 12

issue

  • 1