Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis. Academic Article uri icon

Overview

abstract

  • IQG-607 is a metal complex previously reported as a promising anti-tuberculosis (TB) drug against isoniazid (INH)-resistant strains of Mycobacterium tuberculosis Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing, and all sequenced colonies carried alterations in the katG gene. The katG(S315T) mutation was sufficient to confer resistance to IQG-607 in both MIC assays and inside macrophages. Moreover, overexpression of the InhA(S94A) protein caused IQG-607's resistance.

publication date

  • January 25, 2018

Research

keywords

  • Antitubercular Agents
  • Drug Resistance, Bacterial
  • Ferrous Compounds
  • Isoniazid
  • Mycobacterium tuberculosis
  • Tuberculosis, Multidrug-Resistant

Identity

PubMed Central ID

  • PMC5786794

Scopus Document Identifier

  • 85040999746

Digital Object Identifier (DOI)

  • 10.1128/AAC.01601-09

PubMed ID

  • 29158273

Additional Document Info

volume

  • 62

issue

  • 2