Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications. Review uri icon

Overview

abstract

  • The goal of cancer immunotherapy is to establish new or boost pre-existing anticancer immune responses that eradicate malignant cells while generating immunological memory to prevent disease relapse. Over the past few years, immunomodulatory monoclonal antibodies (mAbs) that block co-inhibitory receptors on immune effectors cells - such as cytotoxic T lymphocyte-associated protein 4 (CTLA4), programmed cell death 1 (PDCD1, best known as PD-1) - or their ligands - such as CD274 (best known as PD-L1) - have proven very successful in this sense. As a consequence, many of such immune checkpoint blockers (ICBs) have already entered the clinical practice for various oncological indications. Considerable attention is currently being attracted by a second group of immunomodulatory mAbs, which are conceived to activate co-stimulatory receptors on immune effector cells. Here, we discuss the mechanisms of action of these immunostimulatory mAbs and summarize recent progress in their preclinical and clinical development.

publication date

  • August 30, 2017

Identity

PubMed Central ID

  • PMC5706611

Scopus Document Identifier

  • 85030158829

Digital Object Identifier (DOI)

  • 10.1038/nrclinonc.2016.65

PubMed ID

  • 29209572

Additional Document Info

volume

  • 6

issue

  • 12