Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities. Review uri icon

Overview

abstract

  • Cancer cells hijack metabolic pathways to support bioenergetics and biosynthetic requirements for their uncontrolled growth. Thus, cancer can be considered as a metabolic disease. In this review, we discuss the main metabolic features of prostate cancer with a particular focus on the link between oncogene-directed cancer metabolic regulation, metabolism rewiring, and epigenetic regulation. The potential of using metabolic profiling as a means to predict disease behavior and to identify novel therapeutic targets and new diagnostic markers will be addressed as well as the current challenges in metabolomics analyses. Finally, diagnostic and prognostic metabolic imaging approaches, including positron emission tomography, mass spectrometry, nuclear magnetic resonance, and their translational applications, will be discussed. Here, we emphasize how targeting metabolic vulnerabilities in prostate cancer may pave the way for novel personalized diagnostic and therapeutic interventions.

publication date

  • October 1, 2018

Research

keywords

  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC6169980

Scopus Document Identifier

  • 85054067780

Digital Object Identifier (DOI)

  • 10.3390/metabo6010010

PubMed ID

  • 29229664

Additional Document Info

volume

  • 8

issue

  • 10