Growth of liver allografts over time in pediatric transplant recipients. Academic Article uri icon

Overview

abstract

  • The liver's capacity to grow in response to metabolic need is well known. However, long-term growth of liver allografts in pediatric recipients has not been characterized. A retrospective review of pediatric recipients at a single institution identified patients who had cross-sectional imaging at 1, 5, and 10 years post-transplant. Using volumetric calculations, liver allograft size was calculated and percent SLV were compared across the different time points; 18 patients ranging from 0.3 to 17.7 years old were identified that had imaging at 2 or more time points. Measured liver volumes increased by 59% after 5 years and 170% after 10 years. The measured liver volumes compared to calculated %SLV for these patients were 123 ± 37%, 97 ± 19%, and 118 ± 27% at 1, 5, and 10 years after transplant, respectively. Our data suggest that liver allografts in pediatric recipients increase along with overall growth, and reach SLVs for height and weight by 5 years post-transplantation. Additionally, as pediatric recipients grow, the livers appear to maintain appropriate SLV.

publication date

  • January 15, 2018

Research

keywords

  • Allografts
  • Liver
  • Liver Transplantation

Identity

PubMed Central ID

  • PMC5820167

Scopus Document Identifier

  • 85040680977

Digital Object Identifier (DOI)

  • 10.1111/petr.13104

PubMed ID

  • 29334158

Additional Document Info

volume

  • 22

issue

  • 2