CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Academic Article uri icon

Overview

abstract

  • The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In vitro, CD209a augments the egg-induced IL-1β and IL-23 production initiated by the related CLRs Dectin-2 and Mincle. While Dectin-2 and Mincle trigger an FcRγ-dependent signaling cascade that involves the tyrosine kinase Syk and the trimolecular Card9-Bcl10-Malt1 complex, CD209a promotes the sustained activation of Raf-1. Our findings demonstrate that CD209a drives severe Th17 cell-mediated immunopathology in a helminthic disease based on synergy between DC-SIGN- and Dectin-2-related CLRs.

publication date

  • January 30, 2018

Research

keywords

  • Cell Adhesion Molecules
  • Lectins, C-Type
  • Membrane Proteins
  • Receptors, Cell Surface
  • Schistosomiasis mansoni
  • Th17 Cells

Identity

PubMed Central ID

  • PMC5815841

Scopus Document Identifier

  • 85044851397

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2018.01.001

PubMed ID

  • 29386115

Additional Document Info

volume

  • 22

issue

  • 5